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An inactive mutant form of GPX4 (the heterozygote of Gpx4_U46S) produces reduced litter size resulting from heterozygous reproduction and impaired sperm fertilization of oocytes in vitro [26]

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List of Abbreviations: GT gamma glutamyl transferase GSSH glutathione disulfide LTC4 leukotriene C 4 GSH glutathione -GC synthetase -glu-cysH synthetase ROS reactive oxygen species ArLD alcohol-related liver disease AST aspartate transaminase ALT alanine transferase ALP alkaline phosphatase MetS metabolic syndrome hsCRP high-sensitivity c-reactive protein Footnotes Competing Interests The authors have no competing interests relating to this work Patient consent for publication Not required

Primary Research Applications Weight Management & Fat Loss Studies Clinical validation demonstrates remarkable 7% body weight reduction over 10 days in diet-induced obese mice without changes in food intake compared to controls